Hypothalamic neurogenesis regulates weight gain
نویسندگان
چکیده
منابع مشابه
Patterns of Maternal Weight Gain During Pregnancy and Birth Weight
Anthropometric parameters are an important indicator of health and nutritional status comprising the whole span of mans life. However, they are not of the same degree of simplicity and sensitivity in assessing the public health status. During recent decades many studies have attempted to examine the relationships of these measurements in order to present simple alternatives for similar purposes...
متن کاملPatterns of Weight Gain and Birth Weight Amongst Indian Women
Background: The timing of maternal weight change in pregnancy may be an important determinant of birth weight. The objective of this study was to measure weight gain patterns from early pregnancy until delivery, and to examine the relationship between prenatal weight gain and low birth weight. Methods: A total of 500 pregnant women within 15-20 days of conception, with confirmed pregnancies and...
متن کاملHypothalamic Neurogenesis as an Adaptive Metabolic Mechanism
In the adult brain, well-characterized neurogenic niches are located in the subventricular zone (SVZ) of the lateral ventricles and in the subgranular zone (SGZ) of the hippocampus. In both regions, neural precursor cells (NPCs) share markers of embryonic radial glia and astroglial cells, and in vitro clonal expansion of these cells leads to neurosphere formation. It has also been more recently...
متن کاملLef1-dependent hypothalamic neurogenesis inhibits anxiety
While innate behaviors are conserved throughout the animal kingdom, it is unknown whether common signaling pathways regulate the development of neuronal populations mediating these behaviors in diverse organisms. Here, we demonstrate that the Wnt/ß-catenin effector Lef1 is required for the differentiation of anxiolytic hypothalamic neurons in zebrafish and mice, although the identity of Lef1-de...
متن کاملEffects of Methylphenidate on Weight Gain and Food Intake in Hypothalamic Obesity
UNLABELLED For patients with a craniopharyngioma (CP), treatment of hypothalamic obesity (HO) and hyperphagia following resection and/or radiotherapy is extremely difficult and few reports have been published on potential drug therapies. Psychomotor stimulant methylphenidate (MPH) has been reported to inhibit food intake (FI). In this paper, we report reduction of body mass index (BMI) and appe...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2012
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn3245